In vivo laser axotomy of a single subbasal fiber (SBF) in an adult mouse. The Ocular Neurobiology laboratory at the Institute for Neurosciences, a joint center of Miguel Hernández University (UMH ...

Rare eye diseases are the leading cause of untreatable blindness in Europe and affect people of all ages. The RESTORE VISION scientific team has identified seven rare ocular conditions that impact the ...

(2) Using western blot and immunohistochemical analyses, authors first show that MLCK expression is increased in DRG sensory neurons following peripheral axotomy, concomitant to an increase in MLC ...

MLCK and phosphor-MLC expression increased in sensory neurons after peripheral axotomy. (A-D) Sciatic nerve axotomy was performed 3 days before and L4-L5 DRG tissues were collected for Western ...

Aim: Nimodipine has shown neuroprotective effects in several studies; however, the specific targets and mechanisms remain unclear. This study aims to explore the potential targets and mechanisms of ...

Inflammatory and injury-induced skeletal pain are common conditions, and both conventional nonselective NSAIDs and the newer cyclo-oxygenase-2-specific inhibitors are widely used as post-traumatic ...

Figure 1: Neuroprotection by bFGF is associated with increased expression of activin βA mRNA. Recently, a different type of interaction between bFGF and the TGF-β superfamily was reported from ...

Due to the prevalence of chronic pain worldwide, there is an urgent need to improve pain management strategies. While opioid drugs have long been used to treat chronic pain, their use is severely ...

2 Co-directors Peripheral Nerve Clinic, St. Josephs Health Care, London, Ontario, Canada 3 Roth-McFarlane Hand and Upper Limb Centre, St. Josephs Health Care, Western University, London, Ontario, ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Axon pruning is a unique process neurons ...

J Biol Chem. 2002 Feb 22; 277(8):6511-6519. 2001/12/04 [aheadofprint]. Zhou Y, Deneris E, Zigmond RE. (2001) Nicotinic acetylcholine receptor subunit proteins alpha7 and beta4 decrease in the superior ...