ECHS1 和 CDYL 可将巴豆酰辅酶 A 转化为 β- 羟基丁酰辅酶 A（β-hydroxybutyryl-CoA），后者在线粒体中经过脱氢和硫解作用可转化为乙酰辅酶 A（acetyl-CoA），进而进入三羧酸（TCA）循环。重要的是，乙酰转移酶能够把巴豆酰辅酶 A 上的巴豆酰基转移到诸如组蛋白、酶和 ...

Insufficient acetyl-CoA derails the immune system's ability to protect the body. Until now, however, it was unclear exactly how immune cells maintained their acetyl-CoA reserves.

A study from Van Andel Institute reveals that immune cells use two pathways, ACLY and ACSS2, to produce acetyl-CoA, an essential metabolite for fighting infection and cancer. These findings highlight ...

The initial step for such fatty acid synthesis is acetyl-CoA carboxylation to malonyl-CoA with the help of the enzyme acetyl-CoA carboxylase, which is mostly taking place in liver cells ...