This study presents an enhanced nuclease prime editor (uPEn) that significantly improves gene knock-in and knockout efficiency in mammalian zygotes.

This year marks the 25th anniversary of Shon Walters' furniture and functional art business, Eccentric Wood. He has made his living off of consistent commissions throughout the years. He was the sole ...

Colossal Biosciences, a Texas-based company, genetically engineered a woolly mouse, marking an achievement toward its goal of ...

Researchers are using gene editing techniques to introduce beneficial traits like polled and disease resistance, as well as ...

Sleep and fertility are closely linked, as frequent snoring was associated with poor IVF outcomes and biochemical pregnancy ...

Colossal Biosciences has revealed the world's first 'woolly mice', after engineering rodents to grow thick, warm coats using mammoth DNA.

Harvesting eggs: Collect fertilized eggs (zygotes) from a female mouse shortly after mating. Microinjection: Using a specialized micropipette, inject the DNA construct into the pronucleus of the ...

Construct design: Create the DNA sequence (transgene) you want to introduce, including regulatory elements to control its ...

This month's cover highlights the article Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling by Joseph, Misha Kalarikkal and colleagues. The image shows a human ...

The service includes: Design of guide RNAs (gRNAs) and single-stranded oligo donors. Ordering of Cas9/gRNAs. Microinjection of reagents into zygotes and transfer microinjected embryos into surrogate ...