Figure 3: Mutation of the RIPK1 RHIM domain prevents TNF-induced association of RIPK1 with RIPK3 and necroptosis. Figure 4: RHIM-dependent RIPK1 function prevents MLKL–ZBP1-mediated necroptosis ...

TIR-domain-containing adapter-inducing interferon-β (TRIF), and ZBP1. In addition to necroptosis, RIPK3 promotes inflammatory signaling during tumor necrosis factor (TNF) - and TLR - induced ...