The most powerful weapons in the "Star Trek" universe tend to be the ones that can wipe out millions in a single blow, but handheld weapons aren't to be ignored.

Though this initially led to the assault on Earth that claimed 7 million lives, the Sphere Builders eventually lost the trust of the Xindi Primates, Arboreals, and Aquatics.

In the 22nd century, the Xindi were tricked into attacking Earth by the Sphere Builders, a faction in the Temporal Cold War who convinced the Xindi that humanity was destined to destroy them.