The treatment of TB involves a combination of several antibiotics. These are aimed at reducing the risk of transmission, ...
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普托马尼是全球结核病联盟开发的新一代抗结核药物,于2019年获美国 FDA 批准上市。作为一种全新的硝基咪唑类化合物,普托马尼具有独特的多重作用机制,既能在有氧环境下抑制分枝杆菌酸的生物合成,阻碍细胞壁合成,杀死正在复制的结核分枝杆菌,又能在厌氧环境下释放一氧化氮,对非复制菌产生呼吸毒性作用,同时还能通过靶向戊糖磷酸化途径,造成磷酸戊糖的积累,导致甲基乙二醛的毒性蓄积,使细胞生长停滞。
Drug resistance in Mycobacterium tuberculosis arises from the man-made selection of mutants that result from spontaneous chromosomal alterations. Preventing the development of drug-resistant TB ...
The study, led by researchers with Medecins San Frontieres, analyzed data on adult patients with microbiologically confirmed multidrug-resistant or rifampicin-resistant (MDR/RR)-TB and pre-extensively ...
“In addition, 91 Line Probe Assay labs and 69 liquid culture testing laboratories have been established in the country for diagnosis of MDR-TB and XDR-TB." In turn, the panel has raised a concerning ...
The study, led by researchers with Medecins San Frontieres, analyzed data on adult patients with microbiologically confirmed multidrug-resistant or rifampicin-resistant (MDR/RR)-TB and pre-extensively ...