Sarepta Therapeutics Inc. (NASDAQ:SRPT) is a commercial-stage biopharmaceutical company that discovers and develops ...

Here, we present a replication-competent Sindbis viral vector that has an hsvtk suicide gene incorporated into ns3, ... Wild-type Sindbis virus RNA genome has two major groups of genes: ...

Researchers discovered that HSV-1 (herpes simplex virus) actively reshapes the 3D layout of human DNA within hours of ...

Moreover, most regulatory agencies require that vector manufacturing lots intended for use in humans must be tested for replication competent viruses, which adds an additional complication to the ...

In the world of viral research, uncovering a virus’s weaknesses is often a painstaking process that requires years of ...

While CoV genome replication necessitates continuous RNA synthesis ... was a viable vaccine prospect for this virus and an intriguing platform for vector-based vaccine generation because it ...

The coronavirus that causes COVID-19, SARS-CoV-2, is known as a positive-strand RNA virus because of the way it stores and makes copies of its genetic material. Many other important pathogens such as ...

Researchers offer new insights on how subunits of the influenza virus polymerase co-evolve to ensure efficient viral RNA replication. New insights on how subunits of the influenza virus polymerase ...

The lentiviral vector, modified from HIV-1, was known to infect non-dividing cells (3). A lentiviral vector system was then developed in an attempt to find a viral vector system that could achieve ...

“This protein has a flexible region, can form oligomers, binds RNA, the norovirus’s genetic material, and plays an essential role during viral replication making copies of the viral RNA. All these ...

The authors developed a non-transgenic genome editing approach in tobacco by delivering CRISPR/Cas9 with an engineered eggplant mottled dwarf virus (EMDV) vector, a negative-strand RNA virus ...