These vector particles, without an RNA genome encoding structural proteins ... A safety mechanism should ideally be directly linked with the viral replication machinery to tightly control its ...

and Jeanne M. Rowe Center for Research in Virology at the Morgridge Institute and professor of oncology and molecular virology at UW–Madison, first revealed the existence of this crown-like viral RNA ...

Such a response can be weaponized against malignant cells by modifying T cells with DNA or RNA coding ... chances that replication competent viruses might be generated during vector production.

Researchers offer new insights on how subunits of the influenza virus polymerase co-evolve to ensure efficient viral RNA replication. New insights on how subunits of the influenza virus polymerase ...

The scientists have uncovered that certain RNA viruses take control of a cellular enzyme to design a replication compartment on the cell's membrane filled with PI4P lipids. Those lipids ...

"Given this massive investment of resources, viral RNA genome replication is arguably one of the most important processes in infection, and It is already a major target for virus control ...

"Given this massive investment of resources, viral RNA genome replication is arguably one of the most important processes in infection, and It is already a major target for virus control ...

SARS-CoV-2 replication begins with cellular entry and release of viral RNA into the cytoplasm. The positive-stranded genomic RNA (gRNA) serves as a template for translating viral proteins and ...

The authors developed a non-transgenic genome editing approach in tobacco by delivering CRISPR/Cas9 with an engineered eggplant mottled dwarf virus (EMDV) vector, a negative-strand RNA virus ...

It is also why developing highly effective vaccines against RNA viruses remains challenging. A second, indirect consequence of the low-fidelity replication process is the small size of the viral ...

Lentiviruses are characterized by an envelope, capsid and a RNA genome. The lentiviral vector was engineered so it did not contain any viral-coding genes whilst maintaining genes for replication and ...