In the valproate treated group, the latency of epileptic episodes (SD) was significantly higher than the PTZ alone group, 1095.71 (49.56) vs 55.00 (1.80) sec, respectively.

Valproic acid dissociates to form valproate ions in the body, which has numerous effects on the neuronal tissue in the brain. This accounts for its broad clinical activity and use in several ...

Cite this: In Bipolar Disorder, Lithium alone or with Valproate is More Effective than Valproate Alone - Medscape - Feb 01, 2010. Abstract and Introduction Comment ...

The risks of neurodevelopmental disorders associated with paternal use of valproate during spermatogenesis, JAMA Network Open (2025). DOI: 10.1001/jamanetworkopen.2025.12139 , jamanetwork.com ...

Among 28,952 women with a recorded epilepsy diagnosis, 1,030 had topiramate, 800 had valproate, and 4,205 had lamotrigine prescriptions filled during the second half of pregnancy.

In addition to the teratogenic effects of valproate, maternal use of the drug during pregnancy has been associated with decreased neurocognitive function in children, 4-18 and increased risks of ...

The combination of valproate, given as a mood stabilizer, with olanzapine was chosen to reduce the required dose of an antipsychotic drug and thus help prevent adverse effects that could lead to ...

Although the number of those badly affected by sodium valproate has been put at 20,000, some campaigners believe the figure could be significantly higher. Janet Williams, ...

The median follow-up was 10.1 years for valproate-exposed children and 10.3 years for unexposed children. A total of 43,903 children (3.6%) were diagnosed with major congenital malformations in ...

Men taking sodium valproate are being warned to use contraception while on the medicine, because of "a potential small increased risk" of neurodevelopmental disorders in their future children ...

Use of lithium vs. valproate as a prophylactic treatment may be associated with adverse kidney outcomes, including AKI, according to recently published research. A team led by Alessandro Bosi, MSc ...

A DRUG dubbed the “new thalidomide” will face stronger restrictions from January, regulators have announced. Valproate — an epilepsy medicine that has been linked to birth defects — will ...