It would be interesting to consider how UBR5 and other regulators of MYC that control MYC ubiquitination levels can tune MYC oncogenic potential. Emerging evidence supports the dynamic MYC turnover by ...

In this review, the ubiquitin-proteasome system will be discussed as a promising source of drug targets for trypanosomal diseases. Both the proteasome and the ubiquitination machinery, which function ...

Ube2v1 modulates the ubiquitin-proteasome system performance separate from autophagy. K63-linked ubiquitination is altered by the manipulation of Ube2v1 and contributes to protein aggregate formation.

The ubiquitin-proteasome system (UPS) is a hierarchical enzymatic cascade that plays an essential role in a broad range of cellular pathways and is found in cytoplasmic and nuclear actions of all ...

Degradation rates of most proteins in eukaryotic cells are determined by their rates of ubiquitination. However, possible regulation of the proteasome's capacity to degrade ubiquitinated proteins has ...

Here we show that in stressed mammalian cells, the proteasome is targeted by autophagy, which requires site-specific ubiquitination of its ubiquitin receptors. The process is mediated by the ...

The ubiquitination of E1 has been also theoretically coupled to the ubiquitination ... Walz, J., Zuhl, F. and Seemuller, E. (1998) The proteasome: Paradigm of a self-compart- mentalizing protease.