The well-studied NF-κB signaling system is a key mediator of the inflammatory response. Large-scale sequencing studies in ...

ERAD targets are selected by a quality control system within the ER lumen and are ultimately destroyed by the cytoplasmic ubiquitin–proteasome system (UPS). The spatial separation between ...

This useful manuscript describes cryo-EM structures of archaeal proteasomes that reveal insights into how occupancy of binding pockets on the 20S protease regulates proteasome gating. The evidence ...

摘要：分子胶是一类新型小分子化合物，通过与细胞内的E3泛素连接酶复合体结合，诱导特定蛋白质的泛素化修饰和降解。在癌症治疗中，分子胶通过选择性降解异常表达的致病蛋白，恢复细胞正常功能，抑制肿瘤生长和扩散。与传统药物相比，分子胶具有更高的选择性和更低的副作用，并可与其他疗法联合使用。尽管目前仍处于研究阶段，但分子胶已展现出巨大潜力，有望成为未来癌症治疗的重要策略，为患者带来新希望。