C.P.), Medicine (C.P.), and Pharmacology (C.P.), University of North Carolina, Chapel Hill. Abstract: The ubiquitin proteasome system (UPS) plays a crucial role in biological processes integral to the ...

Figure 3. Hypothetical model of Ubiquitin Proteasome System (UPS) dysfunction after ischemia-reperfusion injury. Ischemia-reperfusion injury impairs proteasome function through 3 main mechanisms.

The ubiquitin proteasome system is an attractive pharmacological target for the treatment of cancer ... inhibiting distinct subunits of the proteasome in a panel of cell lines in vitro. In a ...

This useful manuscript describes cryo-EM structures of archaeal proteasomes that reveal insights into how occupancy of binding pockets on the 20S protease regulates proteasome gating. The evidence ...

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Here, we will review principles of ubiquitin‐dependent control of gene expression and discuss how breakdown of these regulatory circuits leads to a wide array of human diseases.

model. This work not only extended the application of aptamers to screen small-molecule inhibitors for the undruggable lung cancers, but more importantly provided a new strategy to develop protein ...

Beyond headline-grabbing features, Google laid out a bolder ambition: an operating system for the AI age – not the disk-booting kind, but a logic layer every app could tap – a “world model ...

Fabricated emails showed that the engineer tasked with replacing the system was having an extramarital affair — and the AI model threatened to expose him. The blackmail apparently "happens at a ...

OpenAI is updating the AI model powering Operator, its AI agent that can autonomously browse the web and use certain software within a cloud-hosted virtual machine to fulfill users’ requests.

Anthropic’s newly launched Claude Opus 4 model frequently tries to blackmail developers when they threaten to replace it with a new AI system and give it sensitive information about the ...