Figure 3. Hypothetical model of Ubiquitin Proteasome System (UPS) dysfunction after ischemia-reperfusion injury. Ischemia-reperfusion injury impairs proteasome function through 3 main mechanisms.

Here they show that UBL7 can regulate the ubiquitin-proteasome system to safeguard key proteins during spermatogenesis. Here, Arkinson et al. reconstitute NUB1-mediated FAT10 degradation by the ...

ERAD targets are selected by a quality control system within the ER lumen and are ultimately destroyed by the cytoplasmic ubiquitin–proteasome system (UPS). The spatial separation between ...

This useful manuscript describes cryo-EM structures of archaeal proteasomes that reveal insights into how occupancy of binding pockets on the 20S protease regulates proteasome gating. The evidence ...

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Fabricated emails showed that the engineer tasked with replacing the system was having an extramarital affair — and the AI model threatened to expose him. The blackmail apparently "happens at a ...

Anthropic’s newly launched Claude Opus 4 model frequently tries to blackmail developers when they threaten to replace it with a new AI system and give it sensitive information about the ...

Now this system, called the Responsible Scaling Policy (RSP), faces its first real test. Advertisement Advertisement On Thursday, Anthropic launched Claude Opus 4, a new model that, in internal ...

OpenAI is updating the AI model powering Operator, its AI agent that can autonomously browse the web and use certain software within a cloud-hosted virtual machine to fulfill users’ requests.

Tesla is testing a facelifted Model S Plaid sedan at the Nurburgring. The flagship EV’s subtle aero enhancements should improve downforce. Tesla was also testing a Model Y Performance at the ...

Originally described as a direct competitor to the Tesla Model Y, Xiaomi did not shy away from several direct comparisons during the YU7’s debut event. Considering this is our third post about ...

demonstrating its capability as a foundation model for the Earth system rather than just a foundation model for the atmosphere. Aurora first learns how to generate forecasts in just seconds through ...