Misfolded proteins are the main common feature of neurodegenerative diseases, thereby, normal proteostasis is an important mechanism to regulate the neural survival and the central nervous system ...

The ubiquitin-proteasome system (UPS) is a critical cellular mechanism that regulates protein degradation and is essential for maintaining cellular homeostasis. Among the various components of ...

These data suggest that ubiquitin receptors at the proteasome do not select against chains of a certain linkage type and that local factors determine the presentation of ubiquitin chains to the ...

Oxidative stress generates C-terminal amidated proteins, marking them for removal. FBXO31 targets them to the ubiquitin-proteasome system. Loss of FBXO31 in neurons triggers ALS-like gene expression ...

In contrast, oversized cells that undergo compensatory growth slowdown exhibit a superlinear increase in proteasome-mediated protein degradation, with accelerated protein turnover per unit mass, ...

Therefore, to elucidate the regulatory relationship between PDE9A and CHIP at the single-cell level, this study conducted scRNA-seq of the hippocampus and cerebellum from a rat model. Importantly, ...

In this paper we describe how the Systems Engineering Initiative for Patient Safety (SEIPS) model of work system and patient safety, which provides a framework for understanding the structures, ...

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Tesla has revealed a new-look Model Y meant for the Chinese and other Asian-Pacific markets, marking the first major update to the SUV since its launch in 2020. The redesign comes as Tesla ...

The updated ‘Juniper’ Model Y has launched in China ... which Electrek notes isn’t as strict as the US’ EPA system. Both specs have a top speed of 201 kilometers per hour (about 124 ...

15, 2025 — New observational data and simulation models have confirmed a new type of planet unlike anything found in the Solar System ... 2024 — A new computer model can be used to detect ...

The outbreak of diseases ordinarily results from the disruption of the balance and harmony between hosts and pathogens. Devoid of adaptive immunity, shrimp rely largely on the innate immune system to ...