The abundant homohexameric AAA+ ATPase p97/VCP (Cdc48 in yeast) participates in a wide range of cellular processes, including cell cycle regulation, endoplasmic reticulum (ER)-associated ...

cerevisiae and human. In addition, we also characterzed a ’ulp’ type protease that is able to deconjugate Nedd8 rather than SUMO and a viral protease that removes lysine 48-linked ubiquitin chains two ...

Discovery of a NEDD8 modification system regulating the cell cycle: During in vitro translation analysis of full-length cDNA clones, a ubiquitin-like protein, NEDD8, was found to covalently modify ...

Neddylation is a post-translational modification that conjugates the NEDD8 protein to protein substrates, such as the cullins, which once neddylated join complex to form cullin-RING ubiquitin E3 ...

Please use one of the following formats to cite this article in your essay, paper or report: APA Smith, Yolanda. (2023, July 20). Ubiquitin-Like Modifiers. News-Medical. Retrieved on June 13, 2025 ...

The authors of this article show that EGCG inhibited NEDD8, thus stabilizing HUWE1, a crucial E3 ubiquitin ligase involved in protein degradation. HUWE1 binds and degrades TFR1, a protein ...