The liver exhibits metabolic zonation, with gene expression and metabolic functions distributed across specific zones along ...

The E1 first binds the UBL and catalyzes adenylation of the UBL’s C-terminus, prior to promoting UBL transfer to a downstream E2. Ubiquitin’s Arg 72, which corresponds to Ala72 in the UBL NEDD8, is a ...

Figure 3. Illustration of the consequences of protein modification by ubiquitin and the ubiquitin-like molecules NEDD8, SUMO-1, and SUMO-2/-3. K48 polyubiquitination leads to degradation of the target ...

The glutamine deamidase Cycle inhibitory factor (Cif) from enteric bacteria inactivates CRLs to modulate these processes in the host cell. The covalent attachment of a Ubiquitin-like protein NEDD8 ...

在一项新的研究中，来自德国马克斯普朗克生化研究所和美国内华达大学拉斯维加斯分校的研究人员合作揭示了这些分子机器，相关研究结果近期发表在Nature期刊上，论文标题为“NEDD8 nucleates a multivalent cullin–RING–UBE2D ubiquitin ligation assembly”。 图片来自Kheewoong ...

NEDD8 is a ubiquitin-like modifier most well-studied for its role in activating the largest family of ubiquitin E3 ligases, the cullin-RING ligases (CRLs). While many non-cullin neddylation substrates ...

Thank you for submitting your article "SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function" for consideration by eLife. Your article has been ...

Neddylation, the covalent attachment of ubiquitin-like protein Nedd8, of the Cullin-RING E3 ligase family regulates their ubiquitylation activity. However, regulation of HECT ligases by ...

NEDD8, in plants and yeasts also known as RELATED TO UBIQUITIN (RUB), is an evolutionarily conserved 76 amino acid protein highly related to ubiquitin. Like ubiquitin, NEDD8 can be conjugated to and ...