NEDD8/Rub1 is a ubiquitin (Ub)‐like post‐translational modifier that is covalently linked to cullin (Cul)‐family proteins in a manner analogous to ubiquitylation. NEDD8 is known to enhance the ...

Comparison with surface features of ubiquitin and ubiquitin homologs SUMO-1, RUB-1 and NEDD8 suggest how Nature has utilized this single fold to incorporate similar chemistry into a broad array of ...

Figure 1: Reversible ligation of ubiquitin and Ubls to other proteins. The prevalence of Ubls indicates that attachment of proteins to other proteins is a far more widely employed regulatory ...

The Ubiquitin Proteasome System. The proteasome degradation of specific substrates and ... The COP9 signalosome complex regulates the CRL ligase activity via removing NEDD8 from NEDD8-conjugated ...

The liver exhibits metabolic zonation, with gene expression and metabolic functions distributed across specific zones along ...

Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan ...

The approval comes shortly after Takeda revealed that its NEDD8-activating enzyme inhibitor pevonedistat fluffed its lines in a phase 3 trial in myelodysplastic syndromes and acute myeloid ...

It came after a series of disappointments in that effort, including the failure of NEDD8-activating enzyme inhibitor pevonedistat in phase 3 blood cancer trials. Nuvation is set to launch its ...