The liver exhibits metabolic zonation, with gene expression and metabolic functions distributed across specific zones along ...

Selective protein degradation by the ubiquitin–proteasome pathway is a fundamental regulatory strategy that fulfils essential roles in various cellular processes. In recognition of the central ...

The approval comes shortly after Takeda revealed that its NEDD8-activating enzyme inhibitor pevonedistat fluffed its lines in a phase 3 trial in myelodysplastic syndromes and acute myeloid ...

It came after a series of disappointments in that effort, including the failure of NEDD8-activating enzyme inhibitor pevonedistat in phase 3 blood cancer trials. Nuvation is set to launch its ...