The tumor microenvironment—the complex environment that surrounds cancer cells—is often deprived of nutrients and oxygen, particularly in hard-to-treat cancers like pancreatic cancer.

The authors have benchmarked SCellBOW across diverse datasets, including glioblastoma, breast, and metastatic prostate cancer, and have demonstrated ... and all other cells, tested with a Wilcoxon ...

Chimeric RNA combines operating instructions from two or more different genes; these fusions are found in both healthy cells ... that influence prostate cancer or tumor microenvironment, which ...

The tumor microenvironment (TME) is a highly dynamic and heterogeneous network where immune, stromal, and malignant cells interact to modulate cancer progression and immunotherapy outcomes. The ...

We aimed to study how ZIP4 promotes cancer cachexia via interacting with immune microenvironment. Methods: We evaluated the association between cachexia and several major immune cell types in the ...

distinct cancer types were shown to inhibit glucose uptake and effector function by inducing TIGIT expression in CD8 + T cells, resulting in an impaired anti-tumor immunity. In addition, TIGIT was ...

10Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China. 11National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, ...

Evaluation of single-cell representations using SCellBOW. a-c, UMAP plots for the normal prostate (a), PBMC (b), and pancreas (c ... h, Violin plot for predicted risk scores for mCRPC tumor ...

More information: Tancredi Massimo Pentimalli et al, Combining spatial transcriptomics and ECM imaging in 3D for mapping cellular interactions in the tumor microenvironment, Cell Systems (2025).

A wide range of cancers have been linked to inherited mutations, including some cases of breast cancer, uterine cancer, prostate ... kills cancer cells and shrinks tumors by exposing them to ...