Tumor antigens are typically categorized into two classifications according to their specificity: tumor-associated antigens (TAA) and tumor-specific antigens (TSA). The former represents an antigen ...

Such heterogeneous TME restrict the expression of the wide range of tumor antigens, which impact their recognition/binding of TSA/TAA by CAR –M in TME. Thus, whether tumor microenvironment could ...

2 Cancer antigens are classified as tumor-specific antigens (TSAs) or tumor-associated antigens (TAAs). TSA, exclusive to tumor cells, minimizes on-target off-tumor toxicity (OTOT) risks, whereas TAA, ...

(2) These cells are activated using anti-CD3/CD28 antibodies to stimulate their proliferation. (3) Genetic modification of the T cells is performed by inserting the CAR gene, enabling them to ...

State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University, Nanjing 210093, China Department of Andrology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical ...

Random mutations in cancer generate unique antigens in each individual case. The superiority of autologous vaccines suggests that unique tumor-associated antigens are particularly important in ...

Jan. 28, 2025 — A new study shows that asymptomatic brain metastasis is more common in stage 4 breast cancer patients than previously believed. The study suggests that doctors may need to ...

Autoantibodies and tumor-associated antigens (TAAs) are increasingly recognized as valuable tools in the early detection and diagnosis of various cancers. Autoantibodies are immune proteins that ...

Jan. 30, 2025 — A new study shows that artificial intelligence (AI) can help doctors make better decisions when treating cancer. However, it also highlights challenges in how doctors and AI work ...

High levels of the cancer antigen 15-3 (CA 15-3) can indicate that breast cancer is present or has spread to other parts of the body. Among other things, the CA 15-3 blood test can reflect how ...