Compromised antigen presentation ranks among the top mechanisms that render cancers non-immunogenic (non-responsive to immune ...

University of Pittsburgh, Pittsburgh, PA.

One of the main challenges is the scarcity of truly cancer-specific antigens for precise targeting of solid tumors. The use of engineered small, specific antigen-binding domains, such as nanobodies, ...

T-cell-based immunotherapies have transformed the treatment, offering cures to subsets of cancer patients. The rate-limiting step in developing safe and effective new immunotherapies is the ...

A cornerstone of this approach involves rewiring intracellular signaling pathways governing antigen recognition, activation dynamics ... TME-responsive circuits, such as TGF-β-inducible CAR activation ...

Advancements in mRNA vaccine technology are reshaping medicine, addressing challenges and expanding applications from ...

Milesight, a leading provider of innovative IP-based video surveillance solutions, proudly announces the official launch of its cutting-edge PlateXpert Technology - a transformative advancement in the ...

In particular, T-cell engager bsAbs facilitate immune cell–mediated tumor destruction by linking T cells to tumor antigens. Instead, dual immune checkpoint inhibitors (CPIs) enhance immune activation ...