The strong allogeneic response to donor MHC molecules in transplantation and the weak response to tumor antigens represent two important and divergent but potentially interactive immune responses.

The company’s multi-tumor associated antigen (multiTAA) technology, originally developed at the Baylor College of Medicine in Houston, Texas, USA, is based on the selective expansion of a broad ...

The method triggers immune responses that inhibit melanoma, triple-negative breast cancer, lung carcinoma, and ovarian cancer ...

RNA cancer vaccines are at the forefront of next-generation cancer immunotherapy, showcasing significant potential.

EVM14 received FDA clearance for clinical trials, marking Everest Medicines’ first in-house developed therapeutic to reach ...

C.M. Laumont et al., “Noncoding regions are the main source of targetable tumor-specific antigens,” Sci Transl Med, 10:eaau5516, 2019. In pursuit of safe and effective cancer therapies, researchers ...

Cryptic antigens are part of a protein—known as epitopes—that are usually hidden or inaccessible to the immune system and may be present in tumor cells. By targeting these antigens, the immune ...

EVM14 received U.S. FDA clearance for its IND application, becoming Everest's first internally discovered program, and the first mRNA therapeutic cancer vaccine to be cleared for global clinical ...

Preclinical highlights： EVM14 induced a dose-dependent, antigen-specific immune response in mice and significantly inhibited tumor growth in multiple syngeneic tumor models. As a therapeutic ...

In this cohort study of patients with ovarian cancer, American Indian and Black patients were 23% less likely to have an elevated cancer antigen (CA)-125 level at diagnosis. Current CA-125 thresholds ...

The TCR increases the number and types of proteins available to surveilling T cells. Unlike a CAR, which only detects antigens expressed on the surface of a cell, a TCR can also access the ...

The irradiated tumor demonstrates higher 7E11 binding (here labeled with Cy5.5 ... Ruggiero A, Holland JP, Hudolin T, Shenker L, Koulova, A, Bander N, Lewis JS, Grimm J (2011) Targeting the internal ...