In a case report published in the World Journal of Oncology, an elderly female patient was diagnosed with mast cell leukemia (MCL), with imaging showing extensive osteoblastic metastatic lesions. MCL ...

Digital droplet PCR for the detection of additional TPSAB1 copies encoding alpha-tryptase has become more widely available and is poised to change the diagnostic workflow in individuals with elevated ...

Discover 8 ways mast cell activation syndrome causes widespread symptoms from digestive issues to brain fog, often mistaken ...

基于过敏原提取物或其分子的 IgE 检测（IgE-Assays），分析特定抗体与过敏原的反应；细胞活化测试（Cellular Activation Tests），对嗜碱性粒细胞（Basophils）、肥大细胞（Mast Cells）或淋巴细胞（Lymphocytes）等细胞的过敏反应活性进行分析；还有检测类胰蛋白酶（Tryptase ...

② Inflammatory stimuli increase mast cell tryptase levels, which, through the PAR-2/AKT/mTOR pathway, promote collagen deposition, a process that can be inhibited by APC366. ③ Loss of IL-4/STAT6 ...

Design A clinical assessment and a jejunal biopsy were obtained in IBS-D patients (n=45) and healthy subjects (n=30). Mucosal mast cell number and activation were determined by quantifying CD117 + ...

Secondary sclerosing cholangitis (SSC) is a chronic cholestatic biliary disease, characterized by inflammation, obliterative fibrosis of the bile ducts, stricture formation and progressive ...

Nine samples were not eligible for immunostaining for mast cell tryptase. Bold values indicate statistical significance, italic values indicate a tendency with a borderline statistical significance.

An initial negative peripheral blood screen for KIT D816V does not necessarily rule out a diagnosis of systemic mastocytosis. Three hundred eighty-one patients with anaphylaxis or suspected of having ...

此外，还有非 IgE 检测技术，包括血清类胰蛋白酶（Tryptase）、嗜酸性阳离子蛋白（ECP）、嗜酸性粒细胞衍生神经毒素（EDN）、脂质介质、组胺等的检测，以及一些特殊检测如抗原表位分析、类胰蛋白酶 α/β 1 （TPSAB1）基因检测、丝聚蛋白（FLG）基因突变检测等。

at 24 weeks with 76% of patients achieving at least a >50% reduction from baseline in TSS 89% of patients had >50% decrease in serum tryptase levels by four weeks of treatment In APEX, a ...