Notably, this increase was unaffected by blocking the conventional ER-to-Golgi trafficking protein pathway and the exosomal release pathway, thus confirming that PARK7 was released via an ...

First, Enodia’s small molecules are meant to target proteins earlier in their synthesis pathway, while degraders such as proteolysis-targeting chimeras (PROTACs) and molecular glues target them ...

Until now, treatments have involved blocking the protein in question that builds a so-called signalling pathway, but now the researchers show that by instead doing the opposite and activating the ...

Using lasers and genetically engineered versions of these naturally occurring proteins, known as probes, researchers can precisely activate and deactivate a variety of cellular pathways ...

The dynamic nature of TIRAP interaction with several upstream and downstream signaling proteins in varied inflammatory pathways draws immense curiosity towards the post-translational modifications in ...

Abstract: Pathway-specific protein domain (PSPD) are associated with specific pathways. Many protein domains are pervasive in various biological processes, whereas other domains are linked to specific ...

We utilize these substrates to define a MAD pathway for non-native proteins. The proteasomal degradation of these MAD QC substrates occurs at the MOM and requires specific cytosolic and mitochondrial ...

Scientists have discovered a pathway that functions like a car wash to prevent the buildup of a toxic protein associated with Alzheimer's disease. St. Jude Children's Research Hospital scientists ...

Yu and Koch's work is the first to shed light on this protein turnover pathway. They ran their experiments in yeast, a good model organism that often mimics human cellular processes, and conducted ...

thermophilus and E. coli RNase H. All homologs and ancestral proteins studied populate a similar folding intermediate despite being separated by billions of years of evolution. Even though this ...

Department of Molecular Science and Technology, Ajou University, Suwon, South Korea The toll/interleukin 1 receptor (TIR) domain-containing adaptor protein (TIRAP) plays an important role in the ...