Here, the authors develop hydrocarbon-stapled paxillin-mimetic peptides that act as selective and potent focal adhesion kinase (FAK) scaffold inhibitors to displace FAK from focal adhesions.

Data from the Phase II trial saw three of the seven patients dosed with CAN-2409 surviving for more than 35 months.

Thymidine Kinase 2 deficiency (TK2d) is a rare, life-threatening genetic disorder that primarily ... The total market size in the 7MM was approximately USD 1 million in 2023. TK2d is diagnosed through ...

Your body produces the enzyme creatine kinase (CK) or creatine phosphokinase to keep your muscles functioning properly. Healthcare providers use the CK test to check levels of this protein in your ...

Department of Physiology and Pharmacology, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, ...

After 24 h, the media of all plates was changed, and the wells of each plate received the following six concentrations of GCV or BVDU dissolved in B27N2 media, in one well each: 0 μg/ml (negative ...

Alpha-herpesvirus thymidine kinase (TK) genes are virulence-related genes and are nonessential for viral ... in the nucleoside salvage pathway and have significant substrate diversity, especially the ...