Reversible modifications of cysteine thiols have a key role in redox signaling and regulation. A number of reversible redox modifications, including disulfide formation, S-nitrosylation (SNO) and ...

S-Nitrosylation involves the transfer of a nitroso group to cysteine residues, resulting in the formation of S-nitrosothiols (SNO). This reversible post-translational modification dynamically ...

The remaining two (Cys261 and Cys498) are free thiols and thus available for S-nitrosylation of ACE2 via a reversible nucleophilic attack on nitroso nitrogen to form SNO-protein adducts.

Learning About Memory Loss. A chemical process in the brain called S-nitrosylation - which can be activated by inflammations as well as a variety of airborne toxins - blocks brain cells from ...

More information: Jyoti Srivastava et al, Blocking Nitrosylation Induces Immunogenic Cell Death by Sensitizing NRAS-Mutant Melanoma to MEK Inhibitors, Cancer Research (2025). DOI: 10.1158/0008 ...

Using in vitro reactions, Uehara and colleagues first found that PDI could be inactivated by NO donors such as S-nitrosocysteine (SNOC). The isomerase becomes S-nitrosylated at any of four cysteine ...

Fc/2 subunits’ two domains, CH2 and CH3, each contain one intradomain disulfide bond, Wang and colleagues point out. HILIC provided domain-specific separation of free thiol species at the Fc/2 ...