A research team led by Prof. Xiaoqiang Huang from Nanjing University has developed a novel non-natural dynamic kinetic ...

However, thiamine is also a vital micronutrient for plants; thiamine diphosphate (TDP) is well characterized in its role as an essential coenzyme to enzymes in central metabolism, including carbon ...

The level of the active form of thiamine (thiamine diphosphate) in whole blood is tested to determine a deficiency. Urine tests, which measure how much thiamine is being excreted, might also be used.

DHTKD1 is the E1 component of the 2-oxoadipate dehydrogenase complex, an enzyme involved in the catabolism of (hydroxy-)lysine and tryptophan. Mutations in have been associated with 2-aminoadipic and ...

Because the NUDIX thiamin-phosphatase, which is implicated in de-phosphorylation of toxic oxygenated forms of thiamin diphosphate (Goyer et al., 2013), operates on molecules containing defects in ...

Bringing a knowledge of enzymology into research in vivo and in situ is of great importance in understanding systems biology and metabolic regulation. The central metabolic significance of thiamin ...

Jordan, F. (2003) Current mechanistic understanding of thiamin diphosphate-dependent enzymatic reactions. Natural Product Reports, 20, 184-201. doi:10.1039/b111348h has been cited by the following ...

We summarize the currently available information regarding the state of ionization and tautomerization of the 4'-aminopyrimidine ring of the thiamine diphosphate on enzymes requiring this coenzyme.