Results: We demonstrated that GSDME regulates the survival and differentiation of hematopoietic stem cells (HSCs). The knockout of GSDME reduced the number and ... of pyroptosis and is activated via ...

Exhausted T-cells (Tex) are characterized by the presence of remarkably conserved ... The RBPJ–IRF1 axis has been shown to promote the differentiation of intermediate Tex into terminal Tex (217).

The mammary epithelium derives from multipotent mammary stem cells (MaSCs) that engage into differentiation during embryonic development. However, adult MaSCs maintain the ability to reactivate ...

ARV-393 is Arvinas' investigational PROteolysis TArgeting Chimera (PROTAC) degrader targeting the B-cell lymphoma 6 protein ...

This important paper describes the regulatory pathway of rRNA synthesis by Meioc-Piwil1 in germ cell differentiation in zebrafish. Using the molecular genetic and cytological approaches, the authors ...

This study presents a valuable finding on the direct cytotoxic effects of DuoHexaBody-CD37 in diffuse large B-cell lymphoma, mediated via SHP-1 activation and antibody clustering, independent of ...

Arvinas to present preclinical data for PROTAC BCL6 degrader & ARV-393 at 2025 AACR annual meeting in Chicago: New Haven, Connecticut Wednesday, April 23, 2025, 18:00 Hrs [IST] Ar ...

Zenas BioPharma, Inc. (NASDAQ:ZBIO) is gearing up to report data from several of its ongoing studies using its differentiated B-Cell targeting drug obexelimab for autoimmune disorders. In ...

Lymphocytes are white blood cells that help the body fight infection and disease. The healthy range for an adult is between 1,000 and 4,800 lymphocytes per microliter (µL) of blood. Doctors will ...

T cell exhaustion is a differentiation state that arises when ... Remarkably, even in a terminally exhausted state where PD-1 antibody therapy proved ineffective, miltefosine was still capable ...