We discuss how our current perspectives on telomerase function could be applied to improving human health. Oncogene - Telomerase in the human organism. Skip to main content.

Telomeres are essential genetic elements at chromosome termini maintained in immortal cells by the enzyme telomerase ().Our current understanding of the structure and function of telomeres and ...

Augmenting and regulating telomerase function will have to be performed with precision, walking a narrow line between cell rejuvenation and a heightened risk for cancer development.

Now, the discovery of a second cancer-promoting function for telomerase may put an end to the controversy. Drs. Laura Smith and Hilary Coller, postdoctoral fellows in Dr. Jim Roberts's lab in the ...

Telomerase promotes proliferation of resting stem cells through a mechanism that does not involve the extension of chromosomal telomeres, researchers report in Nature this week. "This is a completely ...

Augmenting and regulating telomerase function will have to be performed with precision, walking a narrow line between cell rejuvenation and a heightened risk for cancer development.

Both male and female sex hormones up-regulate TERT expression and telomerase function in cultured hematopoietic cells. 24 Within families, genetically normal members may inherit short telomeres ...

T-cell activity is often suppressed by the immunosuppressive nature of the tumor microenvironment, contributing to the ...

In an effort to understand and control telomerase activity, researchers have discovered a protein "motif," named TFLY, which is crucial to the function of telomerase. Altering this motif disrupts ...

Home » Uncategorized » Telomerase, even when present, can be turned off with a genetic switch which could be an antiaging breakthroug. Telomerase, even when present, can be turned off with a genetic ...

We next examined the consequences of hTERT and hTR mutations on telomerase function. We first examined the two missense mutations in hTERT, glutamine replacing leucine at residue 55 ...