Researchers tested their method on a library of 559 human kinases and were able to identify new kinases against the library and confirm them through other biochemical assays. Tao said the method they ...

One of the most important classes of human enzymes are protein kinases - signaling molecules that regulate nearly all cellular activities, including growth, cell division, and metabolism.

Enzyme 'atlas' helps researchers decipher cellular pathways Biologists have mapped out more than 300 protein kinases and their targets, which they hope could yield new leads for cancer drugs ...

“Certain MAP kinases are frequently hyperactivated in cancer and they have become drug targets for treatment,” Turk explained. “Understanding how and where kinases act will help us understand their ...

CAMBRIDGE -- One of the most important classes of human enzymes are protein kinases — signaling molecules that regulate nearly all cellular activities, including growth, cell division, and ...

(Medical Xpress) -- Later-stage cancers thrive by finding detours around roadblocks that cancer drugs put in their path, but a Purdue University biochemist is creating maps that will help ...

"Kinases and their substrates are pivotal in cellular signaling pathways, and the ability to visualize these interactions in system-level contexts opens new avenues for understanding their roles ...

Understanding neural protein phosphorylation and the role of different kinases and substrates is now made easier by the newly developed data repository, KANPHOS Signal transduction, or cellular ...

The molecular basis of phospho-tyrosyl-regulation of Src-family and Syk-family protein tyrosine kinases in signaling pathways is a current focus of ... V. A. Martin, N. M. Gorenstein, R. L. Geahlen ...