Spicy food may support a healthier microbiome, too. Though data are limited, “spicy foods appear to increase the microbiome’s ...

Capsaicin, the phytochemical responsible for the spiciness of peppers, has the potential to modulate metabolism via activation of transient receptor potential vanilloid 1 (TRPV1) receptors, which are ...

Scientists have discovered a novel way to relieve pain by targeting TRPV1, a key ion channel involved in sensing heat and physical discomfort ...

Ohio State researchers discovered three natural compounds—capsianoside I, roseoside, and gingerglycolipid A—that reduce the perceived spiciness of chili peppers without altering their capsaicin levels ...

Figure 2.TRPV1 mutant F660S ablates proton activation but not capsaicin or heat activation. (A)An amino‐acid sequence alignment of part of the pore region, including the upper third of TMD6 of human ...

Capsaicin是一种TRPV1激动剂，作用HEK293细胞，EC50为0.29±0.05μM。 储存条件：-20℃，有效期2年，溶入溶剂后-20℃请尽量在一个月内使用。 切下组织，并剪切成小块，置液氮中冻结，研碎或捣碎。或直接冰浴上匀浆。 对于贴壁细胞 ...

Objective: The capsaicin receptor TRPV1 (transient receptor potential vanilloid type-1) may play an important role in visceral pain and hypersensitivity states. In irritable bowel syndrome (IBS), ...

Notably, coexpression of APT1 together with ZDHHC4 almost fully overwhelmed its downregulation of TRPV1 functional protein levels as reflected by the capsaicin-evoked TRPV1 currents (Fig. 7E,F). As ...

Capsaicin is the main ingredient in ointments, lotions, and patches used for pain relief. It interacts with a nerve receptor called TRPV1, which is present in the brain, peripheral nerves, bladder ...

Capsaicin | 辣椒素. 中文名：辣椒素 CAS：404-86-4 存储条件：4°C, protect from light 生物活性：辣椒素 ((E)-Capsaicin) 是辣椒的一种活性成分，是一种 TRPV1 激动剂。 辣椒素具有镇痛、抗氧化、抗炎、神经保护和抗癌作用[1][2]。

In this study, the TRPV1 receptor antagonist (capsazepine) was used to block the activation of the TRPV1 ion channel by capsaicin. The effects of capsazepine, capsaicin, and a combination treatment of ...