Spicy food may support a healthier microbiome, too. Though data are limited, “spicy foods appear to increase the microbiome’s ...

Capsaicin, the phytochemical responsible for the spiciness of peppers, has the potential to modulate metabolism via activation of transient receptor potential vanilloid 1 (TRPV1) receptors, which are ...

Scientists have discovered a novel way to relieve pain by targeting TRPV1, a key ion channel involved in sensing heat and physical discomfort ...

Ohio State researchers discovered three natural compounds—capsianoside I, roseoside, and gingerglycolipid A—that reduce the perceived spiciness of chili peppers without altering their capsaicin levels ...

The compounds may work by interfering with TRPV1 receptors, ... Each sample contained the same amount of capsaicin and dihydrocapsaicin, roughly equivalent to 800 Scoville units, ...

Dietary capsaicin further reduced the increased αENaC activity in WT mice attributed to the HS diet. In contrast, this capsaicin effect was absent in TRPV1 –/– mice. Immunoprecipitation study ...

Figure 2.TRPV1 mutant F660S ablates proton activation but not capsaicin or heat activation. (A)An amino‐acid sequence alignment of part of the pore region, including the upper third of TMD6 of human ...

RTX is an activator of the transient receptor potential vanilloid 1, or TRPV1 ion channel and a super-potent equivalent of capsaicin, the active molecule in hot peppers.

Capsaicin, a TRPV1 ligand, suppresses bone resorption by inhibiting the prostaglandin E production of osteoblasts, and attenuates the inflammatory bone loss induced by lipopolysaccharide. ISRN ...

Bone cancer pain (BCP) is a distinct pain state showing characteristics of both neuropathic and inflammatory pain. On average, almost 46% of cancer patients exhibit BCP with numbers flaring up to as ...

But more research would be needed to confirm this interaction, says Jie Zheng of the University of California, Davis, who studies the capsaicin-TRPV1 system and was not involved in the recent paper.

They act on TRPV1 receptors, the same pain sensors that register spicy heat in your mouth. These receptors are also found throughout the body and are targets for pain relief therapies. Capsaicin ...