Capsaicin, the phytochemical responsible for the spiciness of peppers, has the potential to modulate metabolism via activation of transient receptor potential vanilloid 1 (TRPV1) receptors, which are ...

The capsaicin receptor TRPV1, a member of the transient receptor potential family of non‐selective cation channels is a polymodal nociceptor. Noxious thermal stimuli, protons, and the alkaloid ...

Spicy food may support a healthier microbiome, too. Though data are limited, “spicy foods appear to increase the microbiome’s ...

Background Increased expression of TRPV1 receptors in the airways of chronic cough patients and heightened cough responses to inhaled capsaicin are suggestive of a role for TRPV1 receptors in chronic ...

本研究针对白内障术后后囊膜混浊（PCO）这一常见并发症，探究了TRPV1通道通过钙蛋白酶（Calpain）-蛋白酪氨酸磷酸酶（PTP）通路抑制晶状体上皮细胞上皮-间质转化（EMT）的分子机制。研究人员通过体外和离体实验证实，TRPV1激动剂辣椒素（Capsaicin）通过激活 ...

Grünenthal already sells a topical capsaicin product called Qutenza for ... other joints affected by the condition. Development of TRPV1 agonists for pain isn’t a new concept, but many first ...

The researchers suspect the molecules interact with the TRPV1 receptor, which produces a sensation of burning pain when capsaicin binds to it. But more research would be needed to confirm this ...

Scientists have discovered a novel way to relieve pain by targeting TRPV1, a key ion channel involved in sensing heat and physical discomfort ...

Ohio State researchers discovered three natural compounds—capsianoside I, roseoside, and gingerglycolipid A—that reduce the perceived spiciness of chili peppers without altering their capsaicin levels ...

However, when paired with capsaicin, they seem to tone things down ... this may be because the three compounds interfere with TRPV1 receptors in our mouths, which normally cause us to immediately ...

Epithelial sodium channels play crucial roles in regulating renal sodium reabsorption and blood pressure. The renal transient receptor potential vanilloid 1 (TRPV1) cation channel can be activated by ...