Transient receptor potential vanilloid 1 (TRPV1) affects mood and neuroplasticity in the brain, where its role is poorly understood. In the present study we investigated whether capsaicin (8 ...

TRPV1最初是作为辣椒素（capsaicin）受体被发现的，因此也被称为辣椒素受体或香草素受体1，其发现者David Julius教授凭借在发现感知温度受体上的突出 ...

A computational analysis of cryo-EM data defines the binding mode of capsaicin on TRPV1. A mutational analysis validates these findings, showing specific van der Waals and hydrogen-bonding ...

本研究针对白内障术后后囊膜混浊（PCO）这一常见并发症，探究了TRPV1通道通过钙蛋白酶（Calpain）-蛋白酪氨酸磷酸酶（PTP）通路抑制晶状体上皮细胞上皮-间质转化（EMT）的分子机制。研究人员通过体外和离体实验证实，TRPV1激动剂辣椒素（Capsaicin）通过激活Calpain和PTPN9介导的EGFR去磷酸化，显著抑制 ...

辣椒素-TRPV1相互作用机制。图片来源：Molecules [4] 最近，ACS Reactions小组做了一个勇敢的吃辣实验[5]，他们发现牛奶并不是最佳的解辣饮品，相比之下 ...

Thus, capsaicin-induced inward currents are composed of two components: TRPV1-mediated Na+ influx and anon efflux through anotamin 1 activated by Ca2+ ions entering cells through TRPV1.

Spicy food may support a healthier microbiome, too. Though data are limited, “spicy foods appear to increase the microbiome’s ...

Thus, capsaicin-induced inward currents are composed of two components: TRPV1-mediated Na+ influx and anon efflux through anotamin 1 activated by Ca2+ ions entering cells through TRPV1.

Drs. Takayama and Tominaga in National Institute for Physiological Sciences -- Okazaki Institute for Integrative Bioscience -- clarified that an interaction between capsaicin receptor TRPV1 and ...

His team identified the receptor responsive to capsaicin, TRPV1, and showed that it is also activated by heat and inflammatory chemicals. More recently, he has revealed how scorpion venom targets ...