Recently, increasing numbers of studies have demonstrated that transient receptor potential ankyrin 1 (TRPA1) can be used as a potential target for the treatment of inflammatory diseases. TRPA1 is ...

Department of Physiological Chemistry and Christian Doppler Laboratory for Bioactive Aroma Compounds, Faculty of Chemistry, University of Vienna, Althanstraße 14, 1090 Vienna, Austria ...

“The days of just getting one structure and publishing a paper are over. Now we have the technology to tell complex, interesting stories about the molecular machines that make our cells function.” In ...

Here we identified a group of noncovalent agonists and used them to explore TRPA1 gating through iterative functional analyses, molecular modeling, and structure–activity relationship studies. We show ...

The cation channel TRPA1 transduces a myriad of noxious chemical stimuli into nociceptor electrical excitation and neuropeptide release, leading to pain and neurogenic inflammation. Despite emergent ...

Algomedix Inc., today announced the U.S. Patent and Trademark Office has issued US Patent No. 9,951,046 covering the company’s novel, small molecule modulators of TRPA1 as well as compositions and ...

Transient receptor potential ankyrin 1 (TRPA1) is a membrane-associated cation channel primarily studied in sensory neurons, where it acts as a chemosensor of pungent compounds and mediates pain.

Transient Receptor Potential Ankyrin 1 (TRPA1) is a non-selective cation channel that is expressed in a subset of nociceptive afferent sensory nerves. When activated, TRPA1 can evoke nociceptive ...

This channel gates in response to many irritant and proalgesic agents, and can be modulated by calcium and depolarizing voltage. While the closed-state structure of TRPA1 has been recently resolved, ...

Overall, the behavioral experiments are rigorous and convincing. The functional studies of LPS-mediated activation of TRPA1 require additional experiments to link the behavioral and cellular ...