A single mouse click on the topic tumor necrosis factor (TNF) in PubMed reveals about 50 000 articles providing one or the other information about this pleiotropic cytokine or its relatives.

Cite this: TNF Signaling Inhibition in the CNS: Implications for Normal Brain Function and Neurodegenerative Disease - Medscape - Oct 17, 2008. Abstract and Introduction TNF Receptors ...

A distinct signaling pathway called TNF-α drives the transformation of epithelial cells into aggressive tumor cells. During cancer progression, cells activate their own TNF-α program and become ...

Shi’s study, "Selective suppression of melanoma lacking IFN-γ pathway by JAK inhibition depends on T cells and host TNF signaling," was recently published in Nature Communications. “Concerted efforts ...

Now, after years of studying TNF's cell signaling functions in the vascular system, researchers found that TNF directly impacts how the smallest arteries constrict - and thus profoundly influences ...

Strategies aiming to disrupt TNF signaling may result in increased quality of life (QOL) and delayed tumor progression. Materials and Methods: This phase I/II study evaluated feasibility and efficacy ...

TNF(tumor necrosis factor): Tumor necrosis factor is a substance in your body that causes inflammation. Learn about the role it plays in diseases like rheumatoid arthritis (RA).

Conclusions: Increased TNF-α signaling levels are associated with increasingNCCN and Decipher risk groups and basal subtype. Elevated TNF-α levels in patients with FIR disease tumors had higher risk ...

Finally, administration of etanercept (a clinical TNF-α antagonist) impedes aortic degeneration and dissection, and improves survival in the BAPN-induced AD model, opening new avenues for ...

Cite this: TNF Signaling Inhibition in the CNS: Implications for Normal Brain Function and Neurodegenerative Disease - Medscape - Oct 17, 2008. Abstract and Introduction; TNF Receptors; ...