TLR7, TLR8, and TLR9 are part of a subfamily ... compared to bacterial or viral tRNA. mRNA in bacteria is unmodified, but this is not the case with mammalian mRNA, which contains modified nucleosides.

TLR7 and TLR8) and cytosolic RNA sensors (such as retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) that reduce mRNA translation and stability.