研究结论和讨论部分指出，该研究揭示了孕期小鼠感染 P. gingivalis 导致子代 CP 的机制，即 P. gingivalis 通过增强糖酵解和 H 4 K12la，上调 ADAM17，进而裂解 TGFBR1 和 MerTK，影响腭部融合和骨化。这一发现为解释母亲牙周疾病与子代 CP 的关联提供了理论依据，也为预防 ...

Genetics 2/13 probands had molecular autopsy with pathogenic variants and 1 with phenotypic features of Loeys-Dietz syndrome (LDS) had a TGFBR1 Variant of Uncertain Significance (VUS). In one family, ...

Division of Cardiovascular Surgery, Peter Munk Cardiac Centre, University Health Network, Toronto, ON, Canada (B.S., M.X.D., J.C.Y.C., M.O.). Division of ...