Bicara Therapeutics shows potential to reshape cancer care with ficerafusp alfa and robust funding post-IPO. Find out why ...

Cancer Res (2025) 85 (8_Supplement_1): 2695. Activation of stimulator of interferon genes (STING) has shown great potential to enhance anti-tumor effect and reshape the tumor microenvironment (TME).

Preclinical data further support the potential of dual-antigen and TGF-β-directed vaccines to reshape the tumor microenvironment and drive anti-tumor immunity NEW YORK, April 25, 2025 (GLOBE NEWSWIRE) ...

The IO102-IO103 vaccine targets IDO1 and PD-L1+ cells, generating strong T-cell responses and modulating the tumor microenvironment ... Growth Factor beta (TGF-β). “These data continue to ...

The tumor microenvironment (TME) is a highly complex and continuous evolving ecosystem ... Crosstalk between benign non-immune cells and cancer cells. CAFs secret TGF-β to promote ECM deposition and ...

Cancer-associated fibroblasts (CAFs) are integral components of the tumor microenvironment playing key roles in tumor progression ... Agents like Simtuzumab and EGCG have been evaluated for their ...

Preclinical data further support the potential of dual-antigen and TGF-β-directed vaccines to reshape the tumor microenvironment and drive anti-tumor immunity NEW ... which targets Transforming Growth ...

Interestingly, these processes are all sensitive to the concentration of oxygen present in the microenvironment. Rapidly proliferating cells cause the NSCLC tumor to extend beyond the oxygen ...

Knight Cancer Institute, Oregon Health & Science University, Portland, OR.

The second candidate, IO170, focuses on inhibiting Transforming Growth Factor beta (TGF-β ... cells against both tumor cells and immune-suppressive cells in the tumor microenvironment.