The structure of the endogenous or genetically engineered T-cell receptor (TCR)-CD3 complex can recognize peptides presented by HLA molecules originating from various cellular compartments. Created ...

To enable this innovation, Medigene combined TCR-guided precision targeting with innate NK cell killing. The Company has developed a proprietary universal scaffold that allows its 3S TCRs to function ...

本次研讨会由清华大学祁海教授、斯坦福大学Mark Davis教授、英国弗朗西斯·克里克研究所Carola Vinuesa教授和墨尔本大学Laura ...

点击蓝字关注我们【导读】淋巴细胞活化基因3（LAG3）已成为一种很有前景的癌症免疫疗法靶点，但配体接合时激活LAG3的机制仍不清楚。2025年3月17日，上海科技大学/中国科学院大学的研究团队在期刊《Cell》上发表了题为“Ligand-induce ...

The 2025 season of the TCR Spain kicks off this weekend at the Montmeló circuit in Barcelona with the series presenting an 18-car entry list for the first of five rounds, The series continues its ...

Kimmtrak takes the form of a bispecific T-cell engager (BiTE) molecule, made up of a soluble TCR targeting gp100 expressed on cancer cells fused to a protein that binds CD3 receptors on ...

为解决 CAR-T 细胞疗法的复发问题，研究人员设计 ChTCR，其在识别肿瘤抗原上表现出色，有望对抗肿瘤异质性。 研究人员运用了多种关键技术方法。在细胞相关技术方面，获取多种细胞系并对其进行改造，如利用 CRISPR-Cas9 技术生成表达不同水平抗原的 Nalm-6 细胞变体。同时，通过慢病毒转导和基因编辑技术，将 CAR 和 ChTCR 序列导入 T ...

The mechanisms causing these functional differences were not fully discussed. Discussions touching on possible changes in TCR repertoire diversity between Mu/Hu- and Hu/Hu- T cells would have been ...

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The bispecific antibody targets GPRC5D – which is overexpressed on myeloma cells – as well as CD3 on T cells and is designed to stoke up an immune response against the cancer. It was filed for ...