Initially, tRNA was considered merely a transporter of amino acids. This view changed with the discovery of suppressor tRNA. In 1965, Engelhardt et al. experimentally demonstrated that suppressor ...

To build proteins, cells rely on a molecule called transfer RNA, or tRNA. tRNAs act like protein-building couriers, where ...

Alltrna joins at least three companies developing engineered tRNA molecules to restore protein production in genetic diseases. ReCode Therapeutics is focused on cystic fibrosis, Shape Therapeutics ...

High-resolution quantitative profiling of tRNA abundance and modification status in eukaryotes by mim-tRNAseq. Molecular Cell , 2021; DOI: 10.1016/j.molcel.2021.01.028 Cite This Page : ...

To build proteins, cells rely on a molecule called transfer RNA, or tRNA. tRNAs act like protein-building couriers, where ...

A groundbreaking study has shed light on the critical role of a tRNA methylation enzyme, TRMT10A, in supporting brain function. The findings reveal how the absence of TRMT10A leads to a reduction ...

This Review describes our latest understanding of the range of functions of tRNAs. Emerging roles include the tight regulation of tRNA biogenesis to meet the translational needs of different cell ...

We have developed a new method, tRNA-Map, that can analyze RNA-related enzymes using next-generation DNA sequencing. We analyzed tRNA m1A22 methyltransferase (TrmK) using tRNA-Map. Mutation ...

The inception of Alltrna dates back to 2017–18 when Anastassiadis stumbled across tRNA biology during “an exploration” at Flagship Pioneering—the first stage of the venture creation process.

The structure of a key enzyme involved in protein production is revealed by cryo-electron microscopy (cryo-EM). Using cryo-EM, researchers at Goethe University (Frankfurt, Germany) shed light on ...

A study conducted by a research team from Kumamoto University has shed light on the critical role of a tRNA methylation enzyme, TRMT10A, in supporting brain function. The findings reveal how the ...