Here, we present a computational framework for unbiased combinatorial polyfunctionality analysis of antigen-specific T-cell subsets (COMPASS). COMPASS uses a Bayesian hierarchical framework to ...

A new platform comprehensively profiles CAR T-cells during manufacturing, revealing phenotypic shifts. This allows for ...

5-Prime | T-Cell Subsets: On the Immunity Warpath How do T cells recognize their targets? The acquired immune system consists of two major cell types, T and B cells, which recognize specific antigens.

T cells are the immune system’s frontline fighters. When they detect danger, they rapidly multiply and transform into ...

Scientists and clinicians at University College London (UCL) and Great Ormond Street Hospital (GOSH) have discovered a small subset of T-cells that may play a key role in whether chimeric antigen ...

Findings indicate that frequent COVID-19 booster shots do not weaken T-cell responses, alleviating concerns for vulnerable ...

While they have no direct involvement in neutralizing foreign substances, CD4+ T cells have various functions that help produce a vigorous immune response. Though various subsets of them exist ...

"Our results showed that a subset of T cells, labeled as CD8-fit T cells, are capable of high motility and serial killing, found uniquely in patients with clinical response," reports first author ...

A team of cancer researchers, led by the University of Houston, has discovered a new subset of T cells that may improve the outcome for patients treated with T-cell therapies. T cell-based ...