Mayo Clinic's Molecular Neurotherapeutics Lab demonstrated that maternal immune insults perturb microglial phenotypes and ...

The model reveals how proteins like synapsin-1 and tomosyn-1 regulate the recycling of vesicles, enabling synaptic transmission even at high firing rates. This breakthrough clarifies a long-standing ...

Imaging synaptic vesicles in 3D Date: December 3, 2024 Source: Max Delbrück Center for Molecular Medicine in the Helmholtz Association Summary: Researchers have used cryo-electron tomography to ...

In this study, Kravčenko and colleagues advance our understanding of synaptic vesicles (SVs), crucial for neurotransmitter storage and release. Employing cryoelectron tomography, the study ...

For synaptic transmission, synaptic vesicles undergo rapid turnover – they are consumed for the transmitter release and subsequently recovered from the plasma membrane via endocytosis. During this ...

Chemical synapses contain substantial numbers of neurotransmitter-filled synaptic vesicles, ranging from approximately 100 to many thousands. The vesicles fuse with the plasma membrane to release ...

Neurotransmitter-filled synaptic vesicles (SVs) mediate synaptic transmission and are a hallmark specialization in neuronal axons. Yet, how SV proteins are sorted to presynaptic nerve terminals ...

Synaptic vesicles are tiny, membrane-enclosed compartments that package and release messenger compounds, such as neurotransmitters, in neurons. Researchers have identified common proteins ...

Synaptophysins 1 and 2 and synaptogyrins 1 and 3 constitute a major family of synaptic vesicle membrane proteins. Unlike other widely expressed synaptic vesicle proteins such as vSNAREs and ...

This implies that cells should preferentially rely on newly produced ones. We tested this hypothesis in cultured hippocampal neurons, focusing on synaptic transmission. We found that newly synthesized ...

ABSTRACT: Our recent coarse-grained (CG) molecular dynamics (MD) simulations of membranes with a hemifused-ribbon (λ-shaped) geometry showed curvature-driven demixing leading to enrich ment in ...