Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China ...

While the presence and significance of melanin have long been accepted, its exact chemical makeup remains unclear. Melanin has an inherent diversity of structure and complexity, making understanding ...

Structure-based drug design is the design and optimization of a chemical structure with the goal of identifying a compound suitable for clinical testing — a drug candidate. It is based on ...

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These adaptive shape morphing structures can twist to improve water ... develop an AFM-based nanorheology platform to measure local molecular mobilities and spatial correlations in lateral ...

We also provide conda-packed file here. Download it and then unzip it in your conda/envs/dir. For me, the directory is ~/.conda/envs. Special thanks to the creators and organizers of zenodo, which ...

Worst-case molecule structure affecting dosing would be a small molecular weight active moiety and a large inactive counterion ... For example, metoprolol tartrate (Lopressor) is an immediate-release ...

Cholesterol is critical for mitochondrial membrane structure and function. Given the emergence of mitochondria as a key factor in the pathogenesis of heart failure, mitochondrial cholesterol ...

The gut microbiome supports health through balanced metabolic exchanges, but in type 2 diabetes rising blood glucose shifts interactions from cooperation to competition, altering cross-feeding ...

Left: Schematic overview of ciliary structure. Primary cilia are made of a central microtubule structure that ... Activation of ciliary receptors could occur through chemical ligands, such as ...

This review summarizes the cell death patterns and molecular mechanisms associated with heart disease and mitochondrial ... Maintaining the integrity of mitochondrial morphology, structure, and ...