New technology develops at an exponential rate, especially today. But what about the year you were born? Here are some of the ...

Structure-based drug design is the design and ... E3 ligase for use with proteolysis targeting chimeras. An activator of DNA polymerase γ restores function to disease-causing mutant variants ...

60, 61 Guidance for partial-genome sequencing is required to define the minimum viable amplicon ... The WHO global viral hepatitis reporting framework could then provide a structure for monitoring the ...

Tune’s treatment is delivered by a lipid nanoparticle to hepatocytes in the liver, where the hepatitis B virus replicates. Within the nanoparticle is mRNA that codes for a protein that induces ...

PBGENE-HBV addresses this challenge by targeting the main source of HBV replication and deactivating integrated HBV DNA in liver cells. “IND clearance to expand the ELIMINATE-B trial for chronic ...

Germany Objectives A major goal of curative hepatitis B virus (HBV) treatments is the reduction or inactivation of intrahepatic viral covalently closed circular DNA (cccDNA). Hence, precise cccDNA ...

In addition to HBsAg, other viral markers such as hepatitis B core-related antigen (HBcrAg) are available, but their potential association with HBV-specific immune responses is not defined yet, which ...

Core Facility Functional Peptidomics, Ulm University Medical Center, 89081 Ulm, Germany Core Unit Mass Spectrometry and Proteomics, Ulm University Medical Center, 89081 Ulm, Germany ...

The persistence of highly-stable, covalently-closed circular DNA within the nuclei of hepatocytes provides an intracellular reservoir of HBV replication, leading to persistent infection.

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HBV embeds its DNA into the host's liver cells, allowing it to become a permanent presence, while hijacking the cell’s own processes to continue replicating. 4 This cunning strategy allows the ...