RECENT clinical studies have demonstrated that osmotic diuresis, with or without urinary alkalinization, will accelerate the renal excretion of drug in patients with barbiturate intoxication. 1 ...

Barbiturates are illegal without a prescription and, in fact, are a controlled substance like narcotics. They can be highly addictive, and withdrawal may produce severe symptoms, including death.

Barbiturates are a type of drug that slows down brain activity. Barbiturates have been used for several conditions, including ...

Barbiturates are a group of medications that are used to induce relaxation and drowsiness in patients, effectively treating many disorders like anxiety, restlessness, seizures, and insomnia.

Barbiturates were first developed in 1864 and became a popular sleeping pill. Between the 1920s and the mid-1950s, barbiturates were practically the only drugs used as sedatives and hypnotics.

The Use of Quantitative Structure-Activity Relationships as an Aid to the Interpretation of Blood Levels in Gases of Fatal Barbiturate Poisoning, Journal of the Forensic Science Society, 21, 3 ...

These drawbacks to self-destruction, as ticked off by Dorothy Parker, do not apply to an overdose of sleeping pills. In recent years the barbiturates have enjoyed alarming popularity as a painless ...

Objectives: To evaluate high-dose barbiturates as a second-tier therapy for pediatric refractory intracranial hypertension complicating severe traumatic brain injury. Design: This is a ...

Malonic acid is a white crystalline solid with a decomposition point of ≈135 °C. It is highly soluble in water and oxygenated solvents. It has numerous commercial uses: It is a precursor to specialty ...

Valium and other modern tranquilizers largely replaced barbiturate drugs 30 years ago. However, barbiturates are still detectable among the pharmaceutical and personal care products that wind up ...

Table 3 shows complications associated with barbiturate coma. Children were treated with barbiturates from 1 to 10 days. Twenty-nine (81%) patients had at least one episode of documented low CPP ...