To investigate the potential conformational change induced by c-di-GMP binding, we have determined the structure of ligand-free STING CTD at 1.9-Å resolution. Superposition of the ligand-free ...

That side-by-side structure is the same as one reported in a recent preprint from Lingyin Li’s group at Stanford University that proposes mechanisms for STING activation, inhibition, and ...

Hao Wu, professor of Biochemistry at Weill Cornell Medical College. "The STING structure provides a remarkable example of the pathogen-host interactions in which a unique microbial molecule ...

While Sting was incredibly complimentary about modern music, he did point out some qualities that could be interpreted as redundant and overly simplistic. Of course, music is music, and it is up for ...

Efficient and site-specific genome engineering can be achieved based on programmable nucleic acid cleavage using CRISPR-Cas surveillance complexes. Structure-function studies on single component Cas ...

Researchers have unlocked the structure of a key protein that, when sensing certain viruses and bacteria, triggers the body's immediate immune response. Researchers at Weill Cornell Medical ...