To investigate the potential conformational change induced by c-di-GMP binding, we have determined the structure of ligand-free STING CTD at 1.9-Å resolution. Superposition of the ligand-free ...

That side-by-side structure is the same as one reported in a recent preprint from Lingyin Li’s group at Stanford University that proposes mechanisms for STING activation, inhibition, and ...

Hao Wu, professor of Biochemistry at Weill Cornell Medical College. "The STING structure provides a remarkable example of the pathogen-host interactions in which a unique microbial molecule ...

Efficient and site-specific genome engineering can be achieved based on programmable nucleic acid cleavage using CRISPR-Cas surveillance complexes. Structure-function studies on single component Cas ...