Sterols, such as cholesterol in our bodies ... yet are synthesized through notoriously long, complex metabolic pathways. Researchers from UC San Diego and the NIH have used a novel combination ...

In one example of a feedback mechanism in mammals, cells switch cholesterol synthesis on or off depending on the availability of sterol. A rewired version of this pathway in yeast acts instead as ...

Already, the researchers are publishing follow-up scholarship and discovery based on their new breakthrough in understanding the sterol synthesis pathway in the parasites. They said drugmakers and ...

The biosynthesis pathways of sterols, essential compounds in all eukaryotic cells, and many of the enzymes involved are evolutionarily conserved in eukaryotes. Although well characterized in most ...

They also studied what would happen if they mutated genes for enzymes "upstream" from this particular enzyme in the multi-step sterol synthesis pathway. And they measured sterol levels in these ...

Already, the researchers are publishing follow-up scholarship and discovery based on their new breakthrough in understanding the sterol synthesis pathway in the parasites. They said drugmakers and ...

This specific sterol plays a key role in the synthesis of cell membranes ... highly regulated via the relevant biochemical signaling pathways. Following this, another enzyme called mevalonate ...

They also studied what would happen if they mutated genes for enzymes “upstream” from this particular enzyme in the multi-step sterol synthesis pathway. And they measured sterol levels in ...