Sterols, such as cholesterol in our bodies ... yet are synthesized through notoriously long, complex metabolic pathways. Researchers from UC San Diego and the NIH have used a novel combination ...

Already, the researchers are publishing follow-up scholarship and discovery based on their new breakthrough in understanding the sterol synthesis pathway in the parasites. They said drugmakers and ...

The squalene peak was identified via comparison with the commercially available authentic standard. The cellular sterol content was analyzed as described by Yue et al. (Yue and Jiang, 2009) and Ren et ...

As GGPP levels increase it binds UBIAD1 and is retained in the Golgi. FPP is also converted to squalene and is the first metabolite committed to the sterol synthesis branch of the pathway (red circles ...

In one example of a feedback mechanism in mammals, cells switch cholesterol synthesis on or off depending on the availability of sterol. A rewired version of this pathway in yeast acts instead as ...

Here, we report a previously unknown C4-methyl sterol biosynthetic pathway involving a sterol methyltransferase rather than the SMOs. We show that both C4α- and C4β-methyl sterols are end products of ...

They also studied what would happen if they mutated genes for enzymes "upstream" from this particular enzyme in the multi-step sterol synthesis pathway. And they measured sterol levels in these ...

Mevalonate kinase deficiency and hyperimmunoglobulin D syndrome Mevalonate kinase (MVK) deficiency is a defect in the first committed step of the isoprenoid-sterol pathway, which is responsible for ...