The alternative pathway for formation of bile acids from cholesterol is known to give chenodeoxycholic ... model may be attributable to the chronic state with a combination of reduced absorption and ...

By sequencing a uniform population of cells, we identified a number of CGMs corresponding to a variety of biological functions, including metabolic processes such as protein and cholesterol synthesis, ...

Our analyses suggest that some metabolic reactions may be conserved despite the loss of canonical eukaryotic enzymes, like the sterol side-chain reductase (SSR). Our findings are consistent with the ...

However, this route of methane synthesis is not yet well established, with a dearth of knowledge on the fundamental mechanism, reaction pathways, and development of materials tailored to improve the ...

This gap arises from the lack of robust computational methods for unbiased cavity identification, cavity-specific ligand design, synthesis, and validation across GPCR topology ... identified ...

Phase-pure samples of a metastable allotrope of silicon, Si-III or BC8, were synthesized by direct elemental transformation at 14 GPa and similar to 900 K and also at significantly reduced pressure in ...

† School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China ‡ Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China Article Views are the ...

Furthermore, we discovered that Scu treatment reversed some of the differences in MASLD metabolic pathways through KEGG enrichment analysis. Compared with the control group, genes upregulated in the ...